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Chromosomal Instability May Not Be a Predictor for Immune Checkpoint Inhibitors from a Comprehensive Bioinformatics Analysis

Immune checkpoint inhibitors (ICIs) have become the standard of care in various cancers, although their predictive tools have not yet completely developed. Here, we aimed to exam the role of 70-gene chromosomal instability signature (CIN70) in cancers, and its association with previous predictors, t...

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Principais autores: Chiao-En Wu, Da-Wei Yeh, Yi-Ru Pan, Wen-Kuan Huang, Ming-Huang Chen, John Wen-Cheng Chang, Jen-Shi Chen, Yu-Chao Wang, Chun-Nan Yeh
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-11-01
Serier:Life
Fag:
CIN70
chromosomal instability
immunotherapy
immune checkpoint inhibitors
tumor mutation burden
microsatellite instability
Online adgang:https://www.mdpi.com/2075-1729/10/11/276
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