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High-risk HPV E6 induces an aneuploidy-prone chromosome congression defect through destabilization of CENP-E

ABSTRACT Chromosomal instability is a common feature of malignancies that arises from persistent defects in chromosome segregation during mitosis. The resulting genetic heterogeneity and acquired malignant traits often characterize advanced disease. However, little is known about the mitotic process...

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Principais autores: Nanami Seshimo, Kanako Hori, Reiko Furuta, Toru Hirota, Ryu-Suke Nozawa
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-06-01
Serier:Journal of Virology
Fag:
CENP-E
aneuploidy
E6 oncoprotein
human papillomavirus
chromosomal instability
chromosome segregation
Online adgang:https://journals.asm.org/doi/10.1128/jvi.00625-26
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