A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

Abstract Background Alzheimer’s disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that mainly affects older adults. One of the pathological hallmarks of AD is abnormally aggregated Tau protein that forms fibrillar deposits in the brain. In AD, Tau pathology...

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Hauptverfasser:	Isabelle Aillaud, Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Lisa Marie Ramirez, Sewar Alkhashrom, Jutta Eichler, Anselm H. C. Horn, Markus Zweckstetter, Eckhard Mandelkow, Heinrich Sticht, Susanne Aileen Funke
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-01-01
Schriftenreihe:	Alzheimer’s Research & Therapy
Schlagworte:	Alzheimer’s disease Tau aggregation inhibitors Phage display D-amino acid peptides Therapy
Online-Zugang:	https://doi.org/10.1186/s13195-022-00959-z
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