Structural basis for recognition of antihistamine drug by human histamine receptor
Crystal structure of human histamine receptor H3R bound to an antagonist PF-03654746 reveals the unexpected binding modes of the antagonist and allosteric cholesterol, which could facilitate the structure-based design of novel antihistamines.
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Portfolio
2022-10-01
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| Schriftenreihe: | Nature Communications |
| Online-Zugang: | https://doi.org/10.1038/s41467-022-33880-y |
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