Structural basis for recognition of antihistamine drug by human histamine receptor
Crystal structure of human histamine receptor H3R bound to an antagonist PF-03654746 reveals the unexpected binding modes of the antagonist and allosteric cholesterol, which could facilitate the structure-based design of novel antihistamines.
I tiakina i:
| Ngā kaituhi matua: | , , , , , , , |
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| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
Nature Portfolio
2022-10-01
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| Rangatū: | Nature Communications |
| Urunga tuihono: | https://doi.org/10.1038/s41467-022-33880-y |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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