Hepatitis C Virus Proteins Core and NS5A Are Highly Sensitive to Oxidative Stress-Induced Degradation after eIF2α/ATF4 Pathway Activation

Hepatitis C virus (HCV) infection is accompanied by increased oxidative stress and endoplasmic reticulum stress as a consequence of viral replication, production of viral proteins, and pro-inflammatory signals. To overcome the cellular stress, hepatocytes have developed several adaptive mechanisms l...

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Autori principali:	W. Alfredo Ríos-Ocampo, María-Cristina Navas, Manon Buist-Homan, Klaas Nico Faber, Toos Daemen, Han Moshage
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2020-04-01
Serie:	Viruses
Soggetti:	hepatitis C virus Core NS5A oxidative stress autophagy-adaptor proteins eIF2a/ATF4 pathway
Accesso online:	https://www.mdpi.com/1999-4915/12/4/425
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