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Hepatitis C Virus Proteins Core and NS5A Are Highly Sensitive to Oxidative Stress-Induced Degradation after eIF2α/ATF4 Pathway Activation

Hepatitis C virus (HCV) infection is accompanied by increased oxidative stress and endoplasmic reticulum stress as a consequence of viral replication, production of viral proteins, and pro-inflammatory signals. To overcome the cellular stress, hepatocytes have developed several adaptive mechanisms l...

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Principais autores: W. Alfredo Ríos-Ocampo, María-Cristina Navas, Manon Buist-Homan, Klaas Nico Faber, Toos Daemen, Han Moshage
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-04-01
Serier:Viruses
Fag:
hepatitis C virus
Core
NS5A
oxidative stress
autophagy-adaptor proteins
eIF2a/ATF4 pathway
Online adgang:https://www.mdpi.com/1999-4915/12/4/425
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