FH535-mediated inhibition of Wnt/β-catenin suppresses CRC growth and invasion and alters MCP1 and MCP2 expression with potential immunological implications

BackgroundThe Wnt/β-catenin signaling pathway plays a key role in colorectal cancer (CRC) progression, but its broader biological effects, when blocked, remain poorly understood. In this study, we examined the direct antitumor effects and the impact on the tumor microenvironment of FH535, a small-mo...

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Principais autores:	Aisha Saleh Janeeh, Bilal Rah, Jasmin Shafarin, Khuloud Bajbouj, Eman Abu-Gharbieh, Mawieh Hamad
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-04-01
Series:	Frontiers in Oncology
Assuntos:	colorectal cancer FH535 monocyte chemoattractant proteins tumor microenvironment Wnt/β-catenin pathway
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1800308/full
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