FH535-mediated inhibition of Wnt/β-catenin suppresses CRC growth and invasion and alters MCP1 and MCP2 expression with potential immunological implications

BackgroundThe Wnt/β-catenin signaling pathway plays a key role in colorectal cancer (CRC) progression, but its broader biological effects, when blocked, remain poorly understood. In this study, we examined the direct antitumor effects and the impact on the tumor microenvironment of FH535, a small-mo...

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Үндсэн зохиолчид:	Aisha Saleh Janeeh, Bilal Rah, Jasmin Shafarin, Khuloud Bajbouj, Eman Abu-Gharbieh, Mawieh Hamad
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2026-04-01
Цуврал:	Frontiers in Oncology
Нөхцлүүд:	colorectal cancer FH535 monocyte chemoattractant proteins tumor microenvironment Wnt/β-catenin pathway
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1800308/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!