Ezetimibe, Niemann-Pick C1 like 1 inhibitor, modulates hepatic phospholipid metabolism to alleviate fat accumulation

BackgroundEzetimibe, which lowers cholesterol by blocking the intestinal cholesterol transporter Niemann-Pick C1 like 1, is reported to reduce hepatic steatosis in humans and animals. Here, we demonstrate the changes in hepatic metabolites and lipids and explain the underlying mechanism of ezetimibe...

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Principais autores:	Hyekyung Yang, Dong Ho Suh, Eun Sung Jung, Yoonjin Lee, Kwang-Hyeon Liu, In-Gu Do, Choong Hwan Lee, Cheol-Young Park
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	ezetimibe hepatic steatosis phospholipids metabolomics lipidomics
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1406493/full
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