Bora bridges Aurora-A activation and substrate recognition of PLK1
Abstract The activation of PLK1 in late G2 is critical for mitotic entry, requiring its phosphorylation by Aurora-A, facilitated by the intrinsically disordered protein Bora. The structural basis of this mechanism has remained unresolved. Here, we present models of the Aurora-A/Bora complex and the...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Springer Nature
2026-01-01
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| Σειρά: | EMBO Reports |
| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.1038/s44319-025-00687-z |
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