CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

Abstract Aurora-A is an essential cell-cycle kinase with critical roles in mitotic entry and spindle dynamics. These functions require binding partners such as CEP192 and TPX2, which modulate both kinase activity and localisation of Aurora-A. Here we investigate the structure and role of the centros...

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Hlavní autoři:	James Holder, Jennifer A Miles, Matthew Batchelor, Harrison Popple, Martin Walko, Wayland Yeung, Natarajan Kannan, Andrew J Wilson, Richard Bayliss, Fanni Gergely
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2024-09-01
Edice:	The EMBO Journal
Témata:	Mitosis Aurora-A Kinase Mitotic Spindle Centrosome
On-line přístup:	https://doi.org/10.1038/s44318-024-00240-z
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