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Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is among the most prevalent chronic liver diseases worldwide. The expression of YTH domain‐containing protein 1 (YTHDC1) is significantly reduced in patients and mouse models with MASLD. Hepatocyte‐specific knockout of YTHDC1...

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Kaydedildi:
Asıl Yazarlar: Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2026-04-01
Seri Bilgileri:Advanced Science
Konular:
lactylation
MASLD
NLRP3
PTPN22
YTHDC1
Online Erişim:https://doi.org/10.1002/advs.202510192
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