Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

ABSTRACT Aerobic glycolysis is a hallmark of cancer, yet the role of the key glycolytic enzyme bisphosphoglycerate mutase (BPGM) in hepatocellular carcinoma (HCC) progression remains unclear. Here, clinical sample analyses revealed that BPGM expression was upregulated in HCC tissues and associated w...

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Principais autores:	Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2026-03-01
Series:	Advanced Science
Assuntos:	BPGM HCC macrophage polarization protein lactylation RET
Acceso en liña:	https://doi.org/10.1002/advs.202518180
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