Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity

Summary: Endoplasmic reticulum to mitochondria Ca2+ transfer is important for cancer cell survival, but the role of mitochondrial Ca2+ uptake through the mitochondrial Ca2+ uniporter (MCU) in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Here, we show that increased MCU expression is...

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Autores principales:	Jillian S. Weissenrieder, Jessica Peura, Usha Paudel, Nikita Bhalerao, Natalie Weinmann, Calvin Johnson, Maximilian Wengyn, Rebecca Drager, Emma Elizabeth Furth, Karl Simin, Marcus Ruscetti, Ben Z. Stanger, Anil K. Rustgi, Jason R. Pitarresi, J. Kevin Foskett
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2025-05-01
Colección:	Cell Reports
Materias:	CP: Cancer CP: Metabolism
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2211124725003985
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