Ehrlichia chaffeensis TRP120 ubiquitinates tumor suppressor APC to modulate Hippo and Wnt signaling

Ehrlichia chaffeensis: TRP120 is a multifunctional effector that acts as a ligand mimic to activate evolutionary conserved eukaryotic signaling pathways Notch, Wnt, Hedgehog and Hippo. In addition, TRP120 is also a HECT E3 ubiquitin ligase known to ubiquitinate several host cell regulatory proteins...

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Библиографические подробности

Главные авторы:	Caitlan D. Byerly, Bing Zhu, Paityn A. Warwick, LaNisha L. Patterson, Nicholas A. Pittner, Jere W. McBride
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2024-03-01
Серии:	Frontiers in Cell and Developmental Biology
Предметы:	Ehrlichia ubiquitination TRP120 adenomatous polyposis coli (APC) Hippo signaling Wnt signaling
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1327418/full
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