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Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression

Application of RNA interference (RNAi) in the clinic has improved with the development of novel delivery reagents (e.g., lipidoids). Although RNAi promises a therapeutic approach at silencing gene expression, practical methods for enhancing gene production still remain a challenge. Previously, we re...

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Автори: Robert F Place, Ji Wang, Emily J Noonan, Rachel Meyers, Muthiah Manoharan, Klaus Charisse, Rick Duncan, Vera Huang, Xiaoling Wang, Long-Cheng Li
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2012-01-01
Серія:Molecular Therapy: Nucleic Acids
Предмети:
CDKN1A
delivery
gene activation
gene therapy
lipid nanoparticles
prostate cancer
saRNA
siRNA
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2162253116300725
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