Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression

Application of RNA interference (RNAi) in the clinic has improved with the development of novel delivery reagents (e.g., lipidoids). Although RNAi promises a therapeutic approach at silencing gene expression, practical methods for enhancing gene production still remain a challenge. Previously, we re...

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Detalhes bibliográficos

Principais autores:	Robert F Place, Ji Wang, Emily J Noonan, Rachel Meyers, Muthiah Manoharan, Klaus Charisse, Rick Duncan, Vera Huang, Xiaoling Wang, Long-Cheng Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2012-01-01
coleção:	Molecular Therapy: Nucleic Acids
Assuntos:	CDKN1A delivery gene activation gene therapy lipid nanoparticles prostate cancer saRNA siRNA
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2162253116300725
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