Improved Immunotherapy Outcomes via Cuproptosis Upregulation of HLA-DRA Expression: Promoting the Aggregation of CD4⁺ and CD8⁺T Lymphocytes in Clear Cell Renal Cell Carcinoma

Immunotherapy has shown promising clinical results in clear cell renal cell carcinoma (ccRCC), but low clinical target response rates due to dysfunction of the major histocompatibility complex (MHC) and an inhibitory tumor immune microenvironment (TIME) have largely limited the associated clinical b...

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Autores principales:	Bowen Wang, Yiwen Liu, Feng Xiong, Chunyang Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2024-05-01
Colección:	Pharmaceuticals
Materias:	cuproptosis human leukocyte antigen tumor-specific major histocompatibility complex-II-II clear cell renal cell carcinoma immunotherapy immune checkpoint inhibitors
Acceso en línea:	https://www.mdpi.com/1424-8247/17/6/678
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