MDK promotes M2 macrophage polarization to remodel the tumour microenvironment in clear cell renal cell carcinoma

Abstract The efficacy of immunotherapy for clear cell renal cell carcinoma (ccRCC), especially advanced ccRCC, is limited, presenting a clinical challenge. This limitation is closely tied to the immune regulation network. Understanding the heterogeneity of the tumour microenvironment (TME) is crucia...

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Autors principals:	Naipeng Shi, Saisai Chen, Dong Wang, Tiange Wu, Nieke Zhang, Ming Chen, Xuefei Ding
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-08-01
Col·lecció:	Scientific Reports
Matèries:	ccRCC Tumour microenvironment M2 macrophage MDK Immunosuppression
Accés en línia:	https://doi.org/10.1038/s41598-024-69183-z
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