Pursing Quinoline-8-Sulfonamide derivatives for the identification of potent NPPs inhibitors: In silico molecular docking, molecular dynamics simulations and density field theory (DFT) studies

Nucleotide pyrophosphatase/phosphodiesterase (NPP) enzymes belong to a broad category of ectonucleotidase enzymes. These NPPs are responsible for hydrolysis of extracellular nucleotides (ATP to AMP) and are therefore important regulators in the purinergic cell signalling. Aberrant expression of NPP...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Jamshed Iqbal, Talha Islam, Mariya al-Rashida, Abdul Hameed, Taseer Iftikhar, Julie Pelletier, Jean Sévigny, Salman Alrokayan, Maria Maqbool, Khurshid Ayub, Tajamul Hussain
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-09-01
סדרה:	Results in Chemistry
נושאים:	Ectonucleotidase inhibitors Enzyme assay P-nitrophenyl 5′-thymidine monophosphate NPP1 NPP3 NPPs inhibitors
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2211715625005399
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