Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitors

Herein, we describe the design, synthesis and biological evaluation of a series of novel non-nucleotide sulfonylurea and sulfonylthiourea based small molecule inhibitors of h-ENPP1, h-ENPP3 and e5′NT. Among the tested compounds, 3b inhibited h-ENPP1 with an IC50 value of 0.11 ± 0.01 µM. Similarly, 4...

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Váldodahkkit:	Abdullah Yahya Abdullah Alzahrani, Abdul Hameed, Abdul Rehman Khan, Julie Pelletier, Jean Sévigny, Jamshed Iqbal
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2024-01-01
Ráidu:	Results in Chemistry
Fáttát:	Ectonucleotidases Sulfonylurea Sulfonylthiourea derivatives Enzyme inhibition Docking studies
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2211715624002443
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