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RANTES/CCL5 Induces Collagen Degradation by Activating MMP-1 and MMP-13 Expression in Human Rheumatoid Arthritis Synovial Fibroblasts

Regulated on activation, normal T expressed, and secreted (RANTES)/CC ligand 5 (CCL5) participates in rheumatoid arthritis (RA) pathogenesis by facilitating leukocyte infiltration, however, its other pathological functions are not fully defined in RA. In the present study, we evaluated the effect of...

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Principais autores: Solomon A. Agere, Nahid Akhtar, Jeffery M. Watson, Salahuddin Ahmed
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017-10-01
Serija:Frontiers in Immunology
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Online dostop:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01341/full
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