RANTES/CCL5 Induces Collagen Degradation by Activating MMP-1 and MMP-13 Expression in Human Rheumatoid Arthritis Synovial Fibroblasts

Regulated on activation, normal T expressed, and secreted (RANTES)/CC ligand 5 (CCL5) participates in rheumatoid arthritis (RA) pathogenesis by facilitating leukocyte infiltration, however, its other pathological functions are not fully defined in RA. In the present study, we evaluated the effect of...

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Hlavní autoři:	Solomon A. Agere, Nahid Akhtar, Jeffery M. Watson, Salahuddin Ahmed
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2017-10-01
Edice:	Frontiers in Immunology
Témata:	rheumatoid arthritis synovial fibroblasts regulated on activation normal T expressed secreted/CC ligand 5 matrix metalloproteinases
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01341/full
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