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A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors

Hematopoietic stem cell and multipotent progenitor (MPP) commitment can be tuned in response to an infection so that their differentiation is biased toward myeloid cells. Here, we find that Bach2, which inhibits myeloid differentiation in common lymphoid progenitors, represses a cohort of myeloid ge...

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Principais autores: Ari Itoh-Nakadai, Mitsuyo Matsumoto, Hiroki Kato, Junichi Sasaki, Yukihiro Uehara, Yuki Sato, Risa Ebina-Shibuya, Mizuho Morooka, Ryo Funayama, Keiko Nakayama, Kyoko Ochiai, Akihiko Muto, Kazuhiko Igarashi
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-03-01
Serier:Cell Reports
Fag:
B cells
gene regulatory network
infection
multipotent progenitors
stem cells
super enhancers
transcription factors
lineage commitment
inner myeloid
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124717302103
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