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Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response

Summary: Heme is known to bind to the intrinsically disordered region (IDR) to regulate protein function. The binding of heme to the IDR of transcription factor BACH2 promotes plasma cell differentiation, but the molecular basis is unknown. Heme was found to increase BACH2 IDR interaction with TANK-...

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Principais autores: Miki Watanabe-Matsui, Shun Kadoya, Kei Segawa, Hiroki Shima, Tadashi Nakagawa, Yuko Nagasawa, Shuichiro Hayashi, Mitsuyo Matsumoto, Mariko Ikeda, Akihiko Muto, Kyoko Ochiai, Long C. Nguyen, Katsumi Doh-Ura, Mikako Shirouzu, Keiko Nakayama, Kazutaka Murayama, Kazuhiko Igarashi
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2025-01-01
סדרה:iScience
נושאים:
Biochemistry
Structural biology
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2589004224027561
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