EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV

Abstract Background Pathological inflammation with a loss of synaptic integrity and function has been implicated in HIV Associated Neurocognitive Disorders (HAND). Although therapeutics exist to increase the lifespan of people living with HIV (PLWH), they are not effective at preventing neuroinflamm...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Jeffrey Koury, Hina Singh, Samantha N. Sutley-Koury, Dominic Fok, Xinru Qiu, Ricky Maung, Benjamin B. Gelman, Iryna M. Ethell, Marcus Kaul
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-06-01
Edice:	Journal of Neuroinflammation
Témata:	Neuroinflammation HIV-1 Ephrin-B EphB Interferon-β Neurotoxicity
On-line přístup:	https://doi.org/10.1186/s12974-025-03481-9
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!