EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV

Abstract Background Pathological inflammation with a loss of synaptic integrity and function has been implicated in HIV Associated Neurocognitive Disorders (HAND). Although therapeutics exist to increase the lifespan of people living with HIV (PLWH), they are not effective at preventing neuroinflamm...

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Главные авторы:	Jeffrey Koury, Hina Singh, Samantha N. Sutley-Koury, Dominic Fok, Xinru Qiu, Ricky Maung, Benjamin B. Gelman, Iryna M. Ethell, Marcus Kaul
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-06-01
Серии:	Journal of Neuroinflammation
Предметы:	Neuroinflammation HIV-1 Ephrin-B EphB Interferon-β Neurotoxicity
Online-ссылка:	https://doi.org/10.1186/s12974-025-03481-9
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