Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system.
BACKGROUND: New drugs are needed to treat visceral leishmaniasis (VL) because the current therapies are toxic, expensive, and parasite resistance may weaken drug efficacy. We established a novel ex vivo splenic explant culture system from hamsters infected with luciferase-transfected Leishmania dono...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2011-01-01
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| Seria: | PLoS Neglected Tropical Diseases |
| Dostęp online: | http://europepmc.org/articles/PMC3039689?pdf=render |
| Etykiety: |
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