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Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system.

BACKGROUND: New drugs are needed to treat visceral leishmaniasis (VL) because the current therapies are toxic, expensive, and parasite resistance may weaken drug efficacy. We established a novel ex vivo splenic explant culture system from hamsters infected with luciferase-transfected Leishmania dono...

Whakaahuatanga katoa

I tiakina i:
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Ngā kaituhi matua: Yaneth Osorio, Bruno L Travi, Adam R Renslo, Alex G Peniche, Peter C Melby
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Public Library of Science (PLoS) 2011-01-01
Rangatū:PLoS Neglected Tropical Diseases
Urunga tuihono:http://europepmc.org/articles/PMC3039689?pdf=render
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