Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells

Abstract In the absence of telomerase, telomere shortening triggers replicative senescence, a tumor suppressor mechanism that is also associated with oncogenic genomic instability. Yet, the precise mechanism that connects these seemingly opposing forces remains poorly understood. To directly study t...

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Bibliografische gegevens

Hoofdauteurs:	Prisca Berardi, Veronica Martinez-Fernandez, Anaïs Rat, Fernando R. Rosas Bringas, Pascale Jolivet, Rachel Langston, Stefano Mattarocci, Alexandre Maes, Théo Aspert, Bechara Zeinoun, Karine Casier, Hinke G. Kazemier, Gilles Charvin, Marie Doumic, Michael Chang, Maria Teresa Teixeira
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Nature Portfolio 2026-03-01
Reeks:	Nature Communications
Online toegang:	https://doi.org/10.1038/s41467-026-70352-z
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