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Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening

In many somatic human tissues, telomeres shorten progressively because of the DNA end replication problem. Consequently, cells cease to proliferate and are maintained in a metabolically viable state called replicative senescence. These cells are characterized by an activation of DNA damage checkpoin...

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Bibliografiset tiedot
Päätekijä: Maria Teresa eTeixeira
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2013-04-01
Sarja:Frontiers in Oncology
Aiheet:
Linkit:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00101/full
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