Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells
Abstract In the absence of telomerase, telomere shortening triggers replicative senescence, a tumor suppressor mechanism that is also associated with oncogenic genomic instability. Yet, the precise mechanism that connects these seemingly opposing forces remains poorly understood. To directly study t...
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| Principais autores: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2026-03-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-026-70352-z |
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