Dual Function pH Responsive Bispecific Antibodies for Tumor Targeting and Antigen Depletion in Plasma

Shedding of membrane-bound cell surface proteins, where the extracellular domain is released and found in the circulation is a common phenomenon. A prominent example is CEACAM5 (CEA, CD66e), where the shed domain plays a pivotal role in tumor progression and metastasis. For treatment of solid tumors...

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Hlavní autoři:	Jan P. Bogen, Steffen C. Hinz, Julius Grzeschik, Aileen Ebenig, Simon Krah, Stefan Zielonka, Harald Kolmar
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2019-08-01
Edice:	Frontiers in Immunology
Témata:	antibody discovery bispecific antibodies common light chain recycling antibodies yeast display CEACAM5
On-line přístup:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01892/full
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