Grabbing the Bull by Both Horns: Bovine Ultralong CDR-H3 Paratopes Enable Engineering of ‘Almost Natural’ Common Light Chain Bispecific Antibodies Suitable For Effector Cell Redirection

A subset of antibodies found in cattle comprises ultralong CDR-H3 regions of up to 70 amino acids. Interestingly, this type of immunoglobulin usually pairs with the single germline VL gene, V30 that is typically very conserved in sequence. In this work, we have engineered ultralong CDR-H3 common lig...

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Principais autores:	Daniel Klewinghaus, Lukas Pekar, Paul Arras, Simon Krah, Bernhard Valldorf, Harald Kolmar, Stefan Zielonka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-01-01
coleção:	Frontiers in Immunology
Assuntos:	bovine ultralong CDR-H3 antibodies bispecific antibodies effector cell redirection NK cell engagers common light chain antibody engineering
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.801368/full
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