Design of orthogonal constant domain interfaces to aid proper heavy/light chain pairing of bispecific antibodies

The correct pairing of cognate heavy and light chains is critical to the efficient manufacturing of IgG-like bispecific antibodies (bsAbs) from a single host cell. We present a general solution for the elimination of heavy chain (HC):light chain (LC) mispairs in bsAbs with [Formula: see text] LCs vi...

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Detalhes bibliográficos

Principais autores:	Kyle A. Barlow, Michael B. Battles, Michael E. Brown, Kaleigh Canfield, Xiaojun Lu, Heather Lynaugh, Morgan Morrill, C. Garrett Rappazzo, Saira P. Reyes, Chanita Sandberg, Beth Sharkey, Christin Strong, Jingfu Zhao, Arvind Sivasubramanian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2025-12-01
coleção:	mAbs
Assuntos:	Bispecific antibodies antibody engineering heavy chain/light chain pairing computational protein design in vitro developability assay developability
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2479531
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