Chemotherapy increases CDA expression and sensitizes malignant pleural mesothelioma cells to capecitabine treatment

Abstract The combination of cisplatin and pemetrexed remains the gold standard chemotherapy for malignant pleural mesothelioma (MPM), although resistance and poor response pose a significant challenge. Cytidine deaminase (CDA) is a key enzyme in the nucleotide salvage pathway and is involved in the...

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Autori principali:	Darya Karatkevich, Tereza Losmanova, Philipp Zens, Haibin Deng, Christelle Dubey, Tuo Zhang, Corsin Casty, Yanyun Gao, Christina Neppl, Sabina Berezowska, Wenxiang Wang, Ren-Wang Peng, Ralph Alexander Schmid, Patrick Dorn, Thomas Michael Marti
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-08-01
Serie:	Scientific Reports
Soggetti:	Chemotherapy Cisplatin Pemetrexed Capecitabine Cytidine deaminase Mesothelioma
Accesso online:	https://doi.org/10.1038/s41598-024-69347-x
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