The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice

Identification of fluorescent dyes that label filamentous protein aggregates characteristic of neurodegenerative disease, such as β-amyloid and tau in Alzheimer’s disease (AD), in a live cell culture system has previously been a major hurdle. Here we show that pentameric formyl thiophene acetic acid...

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Bibliografiska uppgifter

Huvudupphov:	Aviva eTolkovsky, Jack eBrelstaff, Bernardino eOssola, Jonas eNeher, Therese eKlingstedt, Peter eNilsson, Michel eGoedert, Maria Grazia eSpillantini
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2015-05-01
Serie:	Frontiers in Neuroscience
Ämnen:	Neurofibrillary Tangles Alzheimer’s disease Frontotemporal dementia (FTD) Hyperphosphorylated tau Dorsal root ganglion neurons transgenic P301S tau mouse
Länkar:	http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00184/full
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