Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among humans and rhesus macaques

Rhesus macaques (RMs) are a common pre-clinical model used to test HIV vaccine efficacy and passive immunization strategies. Yet, it remains unclear to what extent the Fc-Fc receptor (FcR) interactions impacting antiviral activities of antibodies in RMs recapitulate those in humans. Here, we evaluat...

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Autores principales:	Marina Tuyishime, Rachel L. Spreng, Brady Hueber, Junsuke Nohara, Derrick Goodman, Cliburn Chan, Richard Barfield, Whitney E. Beck, Shalini Jha, Stephanie Asdell, Kevin Wiehe, Max M. He, David Easterhoff, Haleigh E. Conley, Taylor Hoxie, Thaddeus Gurley, Caroline Jones, Nihar Deb Adhikary, Francois Villinger, Rasmi Thomas, Thomas N. Denny, Michael Anthony Moody, Georgia D. Tomaras, Justin Pollara, R. Keith Reeves, Guido Ferrari
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2023-12-01
Colección:	Frontiers in Immunology
Materias:	NK cells ADCC Fc gamma receptor antibody FcR-mediated effector functions rhesus macaques
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260377/full
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