TREM-1 inhibitor specificity and timing of treatment initiation can impact its therapeutic efficacy in cancer and inflammatory disease

BackgroundTriggering receptor expressed on myeloid cells 1 (TREM-1) is a key regulator in inflammation and an emerging therapeutic target in oncology and inflammatory disease.ObjectiveThis study aims to determine whether broad or macrophage-specific TREM-1 blockade demonstrates distinct therapeutic...

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Autore principale:	Alexander B. Sigalov
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-12-01
Serie:	Frontiers in Oncology
Soggetti:	TREM-1 inhibitory SCHOOL peptides pan-TREM-1 blockade macrophage-restricted TREM-1 blockade resolution of inflammation cancer therapy-induced inflammation acute and chronic inflammation diseases
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1689771/full
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