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TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

Abstract Background TREM2 is a transmembrane receptor expressed by myeloid cells and acts to regulate their immune response. TREM2 governs the response of microglia to amyloid and tau pathologies in the Alzheimer’s disease (AD) brain. TREM2 is also present in a soluble form (sTREM2), and its CSF lev...

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Principais autores: Miguel Moutinho, Israel Coronel, Andy P. Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K. Atwood, Shweta S. Puntambekar, Daniel C. Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A. Lasagna-Reeves, Bruce T. Lamb, Stephanie J. Bissel, Kwangsik Nho, Gary E. Landreth
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-02-01
Serier:Genome Medicine
Fag:
TREM2
Soluble TREM2
TREM2 splicing
Alzheimer’s disease
Online adgang:https://doi.org/10.1186/s13073-023-01160-z
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