TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

Abstract Background TREM2 is a transmembrane receptor expressed by myeloid cells and acts to regulate their immune response. TREM2 governs the response of microglia to amyloid and tau pathologies in the Alzheimer’s disease (AD) brain. TREM2 is also present in a soluble form (sTREM2), and its CSF lev...

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Ngā kaituhi matua:	Miguel Moutinho, Israel Coronel, Andy P. Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K. Atwood, Shweta S. Puntambekar, Daniel C. Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A. Lasagna-Reeves, Bruce T. Lamb, Stephanie J. Bissel, Kwangsik Nho, Gary E. Landreth
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2023-02-01
Rangatū:	Genome Medicine
Ngā marau:	TREM2 Soluble TREM2 TREM2 splicing Alzheimer’s disease
Urunga tuihono:	https://doi.org/10.1186/s13073-023-01160-z
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!

TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

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