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JAK2 Inhibition by Fedratinib Reduces Osteoblast Differentiation and Mineralisation of Human Mesenchymal Stem Cells

Several signalling pathways, including the JAK/STAT signalling pathway, have been identified to regulate the differentiation of human bone marrow skeletal (mesenchymal) stem cells (hBMSCs) into bone-forming osteoblasts. Members of the JAK family mediate the intracellular signalling of various of cyt...

Täydet tiedot

Tallennettuna:
Päätekijät: Nihal AlMuraikhi, Hanouf Alaskar, Sarah Binhamdan, Amal Alotaibi, Moustapha Kassem, Musaad Alfayez
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2021-01-01
Sarja:Molecules
Aiheet:
JAK/STAT signalling pathway
JAK2 inhibition
Fedratinib
hMSC-TERT
osteoblast differentiation
in vitro mineralisation
Linkit:https://www.mdpi.com/1420-3049/26/3/606
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