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Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway

Abstract Background The JAK/STAT signaling pathway plays a crucial role in the release of interferons (IFNs) and the proinflammatory response during SARS-CoV-2 infection, contributing to the cytokine storm characteristic of severe COVID-19 cases. STAT3, a key protein in this pathway, has been implic...

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Asıl Yazarlar: Nesrine Ebrahim, Hajir A. Al Saihati, Zahraa Alali, Sabry Younis Mohamed Mahmoud, Ali A. Rabaan, Arigue A. Dessouky, Rabab F. Salim, Ashraf A. Shamaa, Ahmed N. Abdallah, Nehal M. Elsherbiny, Gamal Othman, Abdelnaser A. Badawy, Gianpiero Di Leva, Omnia A. Badr
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2025-05-01
Seri Bilgileri:Stem Cell Research & Therapy
Konular:
COVID-19
MSCs-EVs
JAK/STAT signaling pathway
MicroRNA
Online Erişim:https://doi.org/10.1186/s13287-025-04284-8
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