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Synthesis and evaluation of small molecule-based derivatives as inhibitors of polo-box domain of polo-like kinase-1

Abstract Objectives Polo-like kinase 1 (Plk1) is an important mitotic protein. In particular, this protein is highly overexpressed in many types of tumors and has been identified as a potential biomarker for the treatment and diagnosis of tumors. Plk1 is composed of two domains, an N-terminal kinase...

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Main Authors: Yeo Kyung La, Pethaiah Gunasekaran, Min Su Yim, Gong-Hyeon Lee, Yeon Sil Hwang, Kannan Damodharan, Mi-Hyun Kim, Jeong Kyu Bang, Eun Kyoung Ryu
Format: Artigo
Language:Inglês
Published: SpringerOpen 2023-11-01
Series:Journal of Analytical Science and Technology
Subjects:
Polo-like kinase 1
Polo-box domain
Small molecule
Derivatives
Tumor
Inhibitor
Online Access:https://doi.org/10.1186/s40543-023-00411-3
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