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The GPCR Smoothened on cholinergic interneurons modulates dopamine-associated acetylcholine dynamics, learning, and effort management

Summary: The striatum is a hub for associative learning where fluctuations in dopamine (DA) and acetylcholine (ACh) regulate behavior. ACh is released by cholinergic interneurons (CIN), which integrate diverse inputs that contextualize DA signals and shape behavior. We previously observed that the G...

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Principais autores: Santiago Uribe-Cano, Andreas H. Kottmann
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-05-01
Serier:iScience
Fag:
biological sciences
neuroscience
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004226006991
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