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Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

Studies have shown that the natural flavonoid luteolin has neurotrophic activity. In this study, we investigated the effect of luteolin in a mouse model of Down syndrome. Ts65Dn mice, which are frequently used as a model of Down syndrome, were intraperitoneally injected with 10 mg/kg luteolin for 4...

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Principais autores: Wen-Bo Zhou, Zong-Ning Miao, Bin Zhang, Wei Long, Fang-Xiu Zheng, Jing Kong, Bin Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Medknow Publications 2019-01-01
coleção:Neural Regeneration Research
Assuntos:
nerve regeneration; luteolin; hippocampus; Ts65Dn mice; neurogenesis; ERK; BDNF; nestin; GFAP; NeuN; Down syndrome; neural regeneration
Acesso em linha:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=613;epage=620;aulast=Zhou
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