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Purification of Monoclonal Antibodies Using a Fiber Based Cation-Exchange Stationary Phase: Parameter Determination and Modeling

Monoclonal antibodies (mAb) currently dominate the market for protein therapeutics. Because chromatography unit operations are critical for the purification of therapeutic proteins, the process integration of novel chromatographic stationary phases, driven by the demand for more economic process sch...

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Principais autores: Jan Schwellenbach, Steffen Zobel, Florian Taft, Louis Villain, Jochen Strube
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2016-10-01
Serier:Bioengineering
Fag:
monoclonal antibodies
downstream processing
cation-exchange chromatography
model
simulation
parameter determination
Online adgang:http://www.mdpi.com/2306-5354/3/4/24
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