Código QR

Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature

Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. <i>DPYD</i> gene sequencing reveale...

Descrición completa

Gardado en:
Principais autores: Nedal Bukhari, Abdulraheem Alshangiti, Emad Tashkandi, Mohammed Algarni, Humaid O. Al-Shamsi, Hamoud Al-Khallaf
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2021-07-01
Series:Clinics and Practice
Assuntos:
dihydropyrimidine dehydrogenase
5-Fluorouuracil
chemotherapy
DPYD
polymorphism
Acceso en liña:https://www.mdpi.com/2039-7283/11/3/62
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares