Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature

Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. <i>DPYD</i> gene sequencing reveale...

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Auteurs principaux:	Nedal Bukhari, Abdulraheem Alshangiti, Emad Tashkandi, Mohammed Algarni, Humaid O. Al-Shamsi, Hamoud Al-Khallaf
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2021-07-01
Collection:	Clinics and Practice
Sujets:	dihydropyrimidine dehydrogenase 5-Fluorouuracil chemotherapy DPYD polymorphism
Accès en ligne:	https://www.mdpi.com/2039-7283/11/3/62
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